Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis
نویسندگان
چکیده
منابع مشابه
Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis
While dietary folate deficiency is associated with increased risk for birth defects and other diseases, evidence suggests that supplementation with folic acid can contribute to predisposition to some diseases, including immune dysfunction and cancer. Herein, we show that diets supplemented with folic acid both below and above the recommended levels led to significantly altered metabolism in mul...
متن کاملEffect of Dietary Betaine and Folic Acid Supplementation on Performance, Egg Folate Content and Egg Production of Japanese Quail
A study was conducted to investigate the effects of different betaine (BET) (0.0, 0.5 or 1.0 g/kg) and folic acid (FA) (0.0, 4.0 or 8.0 mg/kg) levels on performance, egg FA concentration and egg production of laying quails using 288 forty-two day-old Japanese quail in a 3 × 3 factorial arrangement of treatment based on randomized complete design. The results showed that none of the performance ...
متن کاملMaternal folic acid supplementation and dietary folate intake and congenital heart defects
BACKGROUND It has been reported that folic acid supplementation before and/or during pregnancy could reduce the risk of congenital heart defects (CHDs). However, the results from limited epidemiologic studies have been inconclusive. We investigated the associations between maternal folic acid supplementation, dietary folate intake, and the risk of CHDs. METHODS A birth cohort study was conduc...
متن کاملEffect of folic acid and glycine supplementation on embryo development and folate metabolism during early pregnancy in pigs.
The present work aimed to determine if different levels of prolificacy either by parity or by genetic origin are linked to folate metabolism. Nulliparous Yorkshire-Landrace (YL) and multiparous YL, and multiparous Meishan-Landrace (ML) sows were randomly assigned to two treatments: 0 ppm or 15 ppm folic acid+0.6% glycine. Supplements were given from the estrus before mating until slaughter on d...
متن کاملFolic acid supplementation, dietary folate intake during pregnancy and risk for spontaneous preterm delivery: a prospective observational cohort study
BACKGROUND Health authorities in numerous countries recommend periconceptional folic acid supplementation to prevent neural tube defects. The objective of this study was to examine the association of dietary folate intake and folic acid supplementation during different periods of pregnancy with the risk of spontaneous preterm delivery (PTD). METHODS The Norwegian Mother and Child Cohort Study...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2017
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2017.171074